Selected Publications

Bellefroid E.J., Bourguignon C., Hollemann T., Ma Q., Anderson D.J., Kintner C., Pieler T. (1996). X-MyT1, a Xenopus C2HC-type zinc finger protein with a regulatory function in neuronal differentiation. Cell. 87, 1191-202.

Bellefroid E.J., Kobbe A., Gruss P., Pieler T., Gurdon J.B., Papalopulu N. (1998) Xiro3 encodes a Xenopus homolog of the Drosophila Iroquois genes and functions in neural specification. EMBO J. 17, 191-203.

Perron M., Opdecamp K., Butler K., Harris W.A., Bellefroid E.J. (1999). X-ngnr-1 and Xath3 promote ectopic expression of sensory neuron markers in the neurula ectoderm and have distinct inducing properties in the retina. Proc Natl Acad Sci USA 96, 14996-5001.

Taelman V., Van Campenhout C., Bellefroid E.J. (2006). The Notch-effector HRT1 gene plays a role in glomerular development and patterning of the Xenopus pronephros anlagen. Development 133, 2961-2971.

Sölter M., Locker M., Boy S., Taelman V., Bellefroid E.J., Perron M., Pieler T. (2006). Characterization and function of the bHLH-O protein XHes2:Insight into the mechanisms controlling retinal cell fate decision. Development 133, 4097-4108.

Verstappen G., van Grunsven L.A., Michiels C., Van de Putte T., Souopgui J., Van Damme J., Bellefroid E.J., Vandekerckhove J., Huylebroeck D. (2008). Atypical Mowat-Wilson patient confirms the importance of the novel association between ZFHX1B/SIP1 and NuRD corepressor complex. Hum Mol Genet. 17, 1175-83.

Souopgui J., Rust B., Vanhomwegen J., Heasman J., Henningfeld K.A., Bellefroid E.J.*, Pieler T. (2008). The RNA-binding protein XSeb4R: a positive regulator of VegT mRNA stability and translation that is required for germ layer formation in Xenopus. Genes Dev. 2347-52.

Nichane M., Ren X., Bellefroid E.J. (2010). Self-regukation of Stat3 activity coordinates cell-cycle progression and neural crest specification. EMBO J. 29, 55-67.

Saulnier A, Keruzore M, De Clercq S, Bar I, Moers V, Magnani D, Walcher T, Filippis C, Kricha S, Parlier D, Viviani L, Matson CK, Nakagawa Y, Theil T, Götz M, Mallamaci A, Marine JC, Zarkower D, Bellefroid EJ. (2013). The Doublesex Homolog Dmrt5 is Required for the Development of the Caudomedial Cerebral Cortex in Mammals. Cerebral Cortex, 23, 2552-2567.

Parlier D, Moers V, Van Campenhout C, Preillon J, Leclère L, Saulnier A, Sirakov M, Busengdal H, Kricha S, Marine JC, Rentzsch F, Bellefroid EJ. The Xenopus doublesex-related gene xDmrt5 is required for olfactory placode neurogenesis. Dev. Biol., 2012, 373, 39-52.

Hanotel J., Bessodes N., Thélie A., Hedderich M., Parrain K., Brandao K., Kricha S. Jorgensen MC, Grapin-Botton A, Serup P., Perron M., Pieler T., Henningfeld K. Bellefroid E.J. (2013). The Prdm13 histone methyltransferase encoding gene is a Ptf1a-Rbpj downstream target that suppresses glutamatergic and promotes GABAergic neuronal fate in the dorsal neural tube. Dev Biol. 386, 340-357.

Nagy, V., Cole, T., Van Campenhout, C., Khoung, T.M., Leung, C., Vermeiren, S., Novatchkova, M., Wenzel, D., Cikes, D., Polyansky, A.A., Kozieradzki, I., Meixner, A., Bellefroid, E.J., Neely, G.G., Penninger, J.M. (2015). The evolutionarily conserved transcription factor PRDM12 controls sensory neuron development and pain perception. Cell Cycle 14, 1799-1808.

Thélie, A., Desiderio, S., Hanotel, J., Quigley, I., Van Driessche, B., Rodary A., Borromeo, M.D., Kricha, S., Lahaye, F., Croce, J., Cerda-Moya, G., Ordono Fernandez, J., Bolle, B., Lewis, K., Sander, M., Pierani, A., Schubert, M., Johnson, J.E., Kintner, C., Pieler, T., Van Lint, C., Henningfeld, K.A., J., Bellefroid. E.J., Van Campenhout C. (2015). Prdm12 specifies V1 interneurons through cross-repressive interactions with Dbx1 and Nkx6 genes in Xenopus. Development, 142, 3416-3428.

De Clercq S, Keruzore M, Desmaris E, Pollart C, Assimacopoulos S, Preillon J, Ascenzo S, Matson CK, Lee M, Nan X, Li M, Nakagawa Y, Hochepied T, Zarkower D, Grove EA, Bellefroid EJ. (2016). Dmrt5 together with Dmrt3 directly controls hippocampus development and neocortical area map formation. Cereb. Cortex doi: 10.1093/cercor/bhw384. [Epub ahead of print]

Young FI, Keruzore M, Nan X, Gennet N, Bellefroid EJ, Li M. (2017). The doublesex-related Dmrta2 safeguards neural progenitor maintenance involves transcriptional regulation of Hes1. Proc Natl Acad Sci U S A. 114, E5599-E5607.

Muralidharan B, Keruzore M, Pradhan S, Roy B, Shetty A, Kinare V, D’souza L, Maheshwari U, Karmodiya K, Suresh A, Galande S, Bellefroid E.J, Tole S (2017). Dmrt5, a novel neurogenic factor, reciprocally regulates Lhx2 to control the neuron-glia cell fate switch in the developing hippocampus. J. of Neurosci. 37(46):11245-11254.

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Bellefroid Lab